On Dec 9, 2009, Celsis sponsored a webcast entitled Rediscovering Ion Chromatography: Applications in Analytical Testing featuring Lokesh Bhattacharyya of the FDA, Phillip DeLand of Dionex and Ryan Williams of Celsis Analytical Services. Rediscover the greener, cost-effective applications for ion chromatography in analytical testing by viewing this free 1 hour webinar. Click here to register and instantly view the webcast.
Celsis Analytical Services has a Dionex ICS-3000 ion chromatograph with conductivity, amperometry, and UV detectors. These very powerful ion chromatographic techniques fill the void between liquid chromatography and gas chromatography analysis. Ion chromatography delivers more selective and sensitive results for difficult-to-analyze materials.
IC is used to differentiate ions by charge, molecular weight, molecular size and hydration sphere. It is often used to determine:
Inorganic anions (fluoride, chloride, iodide)
Cations (sodium, lithium, ammonium ions)
Organic acids (tartrate, citrate, lactic acid)
Additional IC methods and benefits include:
Suppressed ion chromatography makes very low level ion analysis possible
IC with conductivity detection for sulfate, phosphate, fluoride, chloride, iodide, citrate, choline, sulfamate, N-methylpyrrolidine, potassium and sodium
Direct current (DC) amperometry for the analysis of phenols and catechols as well as certain antioxidizing vitamins, aromatic amines, thiols, and sulfides. Examples are β-carotene and acetaminophenol. There are DC amperometry methods in the USP currently for epinephrine.
Integrated pulsed amperometry overcomes the problem of analyzing non-soluble products of an oxidation or reduction.
Pulsed amperometric detection (PAD) for more selective and sensitive analyses of carbohydrates, sugars, and amino acids. Analyzes alcohols, aldehydes, primary, secondary, and tertiary amino acids, and many organic sulfur species, and determines sugars, sugar alcohols, glycols, polysaccharides, and most penicillins, including USP methods for the “mycin” class such as erythromycin and streptomycin.
Celsis Analytical Services can help you validate IC for use. We offer a full range of method development, transfer and validation services with a CGMP-trained staff focused on quality analytical work.
